methyl isocyanate exposure and atypical lymphocytes
نویسندگان
چکیده
[no abstract available]
منابع مشابه
Methyl isocyanate exposure and atypical lymphocytes.
December 3, 1984 marks one of the deadliest chemical disasters of the world took place in Bhopal. The disaster took a toll of 3600 human lives and scores of pets almost instantly. Additional 200 000 people were exposed to the killer gas—methyl isocyanate and its intermediates—to varying degrees.1 Almost 27 years have gone by since occurrence of this tragic event, the health status of the affect...
متن کاملEvaluation of sister chromatid exchange and cytotoxicity in murine tissues in vivo and lymphocytes in vitro following methyl isocyanate exposure.
The purpose of this study was to assess sister chromatid exchange (SCE) levels and cell cycle kinetics in various murine tissues following MIC exposure. Following exposure of mice to MIC, these parameters were measured in bone marrow and alveolar macrophages labeled with BrdUrd in vivo and in peripheral blood and spleen lymphocytes cultured in the presence of BrdUrd in vitro. Target concentrati...
متن کاملExposure and response to methyl isocyanate: results of a community based survey in Bhopal.
In the two weeks immediately after the Bhopal disaster a community based survey was carried out in a series of eight exposed and two non-exposed clusters of households. The primary concern was the effect of the gas (subsequently identified as methyl isocyanate) on the eyes of the victims but data were also sought on respiratory status and the first symptoms of the exposure. No case of blindness...
متن کاملCardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate.
Cardiopulmonary function was assessed four and six months after Fischer 344 rats were exposed to 2 hr to 0, 3, or 10 ppm methyl isocyanate (MIC). During assessment, the rats were challenged with 4 and 8% carbon dioxide (CO2) to stimulate ventilatory drive. Minute ventilation (VE) during CO2 challenge was increased in MIC-treated rats compared to controls when examined 4 months after exposure to...
متن کاملInhalation exposure system used for acute and repeated-dose methyl isocyanate exposures of laboratory animals.
Laboratory animals were exposed by inhalation for 2 hr/day (acute) or 6 hr/day (four consecutive days, repeated dose) to methyl isocyanate (MIC). Exposures were conducted in stainless steel and glass inhalation exposure chambers placed in stainless steel, wire mesh cages. MIC was delivered with nitrogen via stainless steel and Teflon supply lines. Chamber concentrations ranged from 0 to 60 ppm ...
متن کاملBiological effects of short-term, high-concentration exposure to methyl isocyanate. I. Study objectives and inhalation exposure design.
Early reports from India indicated that humans were dying within minutes to a few hours from exposure to methyl isocyanate (MIC). Attempts to explain the cause(s) of these rapid mortalities is where Union Carbide Corporation concentrated its post-Bhopal toxicologic investigations. The MIC studies involving rats and guinea pigs focused primarily on the consequences of acute pulmonary damage. All...
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عنوان ژورنال:
international journal of occupational and environment medicineجلد ۴، شماره ۳ July، صفحات ۲۳۸-۱۶۷
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